EFFECTS OF p-CHLOROPHENYLALANINE, A SEROTONIN DEPLETOR, ON SIDMAN AVOIDANCE RESPONSE IN RATS
نویسندگان
چکیده
منابع مشابه
Participation of different 5-HT receptors in the memory process in rats and its modulation by the serotonin depletor p-chlorophenylalanine.
The memory effects of agonists and antagonists of some serotonin (5-HT) receptor subtypes were examined in experiments on rats using an active avoidance method (shuttle-box). The 5-HT receptor antagonists NAN 190 (1 mg/kg i.p.) and pindolol (6 mg/kg i.p.) improved some indices for memory; the 5-HT2 and 5-HT3 receptor antagonists ritanserin (1 mg/kg i.p.) and ondansetron (0.1 mg/kg i.p.) exerted...
متن کاملEffects of p-chlorophenylalanine (p-CPA) on sleep in olfactory bulb lesioned rats.
The effect of p-CPA and 5-HTP followed by p-CPA on sleep was studied in rats with olfactory bulb lesions (O.B. lesioned rats). In these rats, electrodes were chronically implanted to record the EEG (frontal cortex and dorsal hippocampus), the cervical electromyogram and eye movements. The REM sleep stage was selectively decreased from 24 to 32 hours after 200 mg/kg of p-CPA in the sham lesioned...
متن کاملSimulation of Phenylketonuria in Rats by Extended p-Chlorophenylalanine Treatment
The brain damage which occurs in untreated phenylketonuria probably results from the high plasma phenylalanine concentration prevailing in this condition, as treatment with a low-phenylalanine diet mitigates the situation. The actual cause of the brain damage is not known, but investigations have been carried out with high phenylalanine loads to simulate phenylketonuria and so elucidate the nat...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1970
ISSN: 0021-5198
DOI: 10.1254/jjp.20.607